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Article

A model for genetic complementation controlling the chromosomal abnormalities and loss of heterozygosity formation in cancer.

Cytogenetic and genome research - 1 Jan 2007

Nestor A L, Hollopeter S L, Matsui S-I, Allison D

Abstract excerpt

The relationship between the apparently random chromosomal changes found in aneuploidy and the genetic instability driving the progression of cancer is not clear. We report a test of the hypothesis that aneuploid chromosomal abnormalities might be selected to preserve cell-survival genes during loss of heterozygosity (LOH) formations which eliminate tumor suppressor genes. The LOHs and structurally abnormal...

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Source

Identifiers

PMID: 17431320
DOI: 10.1159/000100406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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