Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of Tumor Suppressor Gene Function in Human Cancer: An Overview

1 Jan 2018

Abstract excerpt

Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research has been conducted over the last few decades to elucidate the role of TSGs in cancer development. In cancer, loss of TSG function occurs via the deletion or inactivation of two alleles, according to Knudson's two-hit model hypothesis. It has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Genomics and Chromatin Dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30562755
DOI: 10.1159/000495956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of Tumor Suppressor Gene Function in Human Cancer: An OverviewPMID 30562755Read ↗

Looking at Thyroid Cancer from the Tumor-Suppressor Genes Point of ViewSemantic proximity Read ↗

Targeting loss-of-function mutations in tumor-suppressor genes as a strategy for development of cancer therapeutic agents.Semantic proximity Read ↗

Tumor suppressor genetics.Semantic proximity Read ↗

Translational Advances in Oncogene and Tumor-Suppressor Gene ResearchSemantic proximity Read ↗

Tumor suppressor genes (TSG).Semantic proximity Read ↗

Exploring the Genetic Orchestra of Cancer: The Interplay Between Oncogenes and Tumor-Suppressor GenesSemantic proximity Read ↗

TSGene 2.0: an updated literature-based knowledgebase for tumor suppressor genes.Semantic proximity Read ↗

[Tumor suppressors--genes and proteins].Semantic proximity Read ↗

TSGene: a web resource for tumor suppressor genes.Semantic proximity Read ↗

Principles of tumor suppression.Semantic proximity Read ↗

[Tumor suppressor genes].Semantic proximity Read ↗

Tumor suppressor genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.