Article

Genomic and Evolutionary Determinants of Two-hit Frequencies in Tumor Suppressor Genes

2026-02-18

Abstract excerpt

While biallelic or “two-hit” inactivation is a central organizing principle for tumor suppressor genes (TSGs), large-scale cancer genomic data reveal substantial heterogeneity in the frequency of such events across genes. This variability reflects diverse selective constraints on allelic disruption, whose biological determinants remain incompletely characterized. Here, we present a comprehensive, allele-specific a...

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Literature Corpus work: 000b2554-9071-5a5b-be98-09c38e7a03f6
DOI: 10.64898/2026.02.17.706175

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