Studies on inherited cancers: outcomes and challenges of 25 years.

Abstract excerpt

Research on the dominantly inherited cancer-susceptibility syndromes over the past 25 years has defined the genetic basis of most of these diseases, usually through linkage analysis on families carrying the disease, and identification and analysis of the genes responsible. At present, almost all of these genes have been cloned and, in most cases, the findings have lent full support to Knudson's original...

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