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Article

Transpresentation of interleukin-15 by IL-15/IL-15Rα mRNA-engineered human dendritic cells boosts antitumoral natural killer cell activity.

Oncotarget - 29 Dec 2015

Van den Bergh Johan, Willemen Yannick, Lion Eva, Van Acker Heleen, De Reu Hans, Anguille Sébastien, Goossens Herman, Berneman Zwi, Van Tendeloo Viggo, Smits Evelien

Abstract excerpt

In cancer immunotherapy, the use of dendritic cell (DC)-based vaccination strategies can improve overall survival, but until now durable clinical responses remain scarce. To date, DC vaccines are designed primarily to induce effective T-cell responses, ignoring the antitumor activity potential of natural killer (NK) cells. Aiming to further improve current DC vaccination outcome, we engineered monocyte-derived DC...

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Identifiers

PMID: 26675759
DOI: 10.18632/oncotarget.6536
PMCID: PMC4792546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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