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Article

Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear Phagocytes.

PloS one - 1 Jan 2015

Yu Huifeng, Sui Yongjun, Wang Yichuan, Sato Noriko, Frey Blake, Xia Zheng, Waldmann Thomas A, Berzofsky Jay

Abstract excerpt

Interleukin (IL)-15 has multiple roles in innate and adaptive immunity, especially regarding CD8+ T cells and natural killer cells. However, the role of IL-15 in regulating differentiation of T helper cell subsets and mononuclear phagocytes (MPs) in different tissues in vivo is unknown. Here we report that IL-15 indirectly regulates Th17 but not other Th subsets in the intestinal lamina propria (LP), apparently...

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Identifiers

PMID: 26600079
DOI: 10.1371/journal.pone.0143001
PMCID: PMC4658142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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