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Article

Role of the PHTH module in protein substrate recognition by Bruton's agammaglobulinemia tyrosine kinase.

The Journal of biological chemistry - 30 Nov 2001

Lowry W E, Huang J, Lei M, Rawlings D, Huang X Y

Abstract excerpt

Defects in Bruton's tyrosine kinase (Btk) are responsible for X chromosome-linked agammaglobulinemia in patients. Mutations in each of the structural domains of Btk have been detected in patients, yet a mechanistic explanation for most of these mutant phenotypes is lacking. To understand the possible role of the unique pleckstrin homology and Tec homology (PHTH) module of Btk, we have compared the enzymatic...

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Identifiers

PMID: 11577078
DOI: 10.1074/jbc.M104449200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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