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Article

Bruton's tyrosine kinase: from X-linked agammaglobulinemia toward targeted therapy for B-cell malignancies.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Jun 2014

Ponader Sabine, Burger Jan A

Abstract excerpt

Discovery of Bruton's tyrosine kinase (BTK) mutations as the cause for X-linked agammaglobulinemia was a milestone in understanding the genetic basis of primary immunodeficiencies. Since then, studies have highlighted the critical role of this enzyme in B-cell development and function, and particularly in B-cell receptor signaling. Because its deletion affects mostly B cells, BTK has become an attractive...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24778403
DOI: 10.1200/JCO.2013.53.1046
PMCID: PMC5073382

Genes

BTK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Bruton's tyrosine kinase: from X-linked agammaglobulinemia toward targeted therapy for B-cell malignancies.PMID 24778403Read ↗

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From identification of the BTK kinase to effective management of leukemiaSemantic proximity Read ↗

The role of Bruton’s tyrosine kinase in autoimmunity and implications for therapySemantic proximity Read ↗

X-linked agammaglobulinemia: lack of mature B lineage cells caused by mutations in the Btk kinase.Semantic proximity Read ↗

Next-generation Bruton's Tyrosine Kinase (BTK) Inhibitors Potentially Targeting BTK C481S Mutation- Recent Developments and Perspectives.Semantic proximity Read ↗

Characterization of Bruton's tyrosine kinase mutations in Mexican patients with X-linked agammaglobulinemia.Semantic proximity Read ↗

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X-Linked Agammaglobulinemia A Clinical and Molecular AnalysisSemantic proximity Read ↗

X-linked agammaglobulinemia (XLA): a genetic tyrosine kinase (Btk) disease.Semantic proximity Read ↗

Identification of Bruton's tyrosine kinase (Btk) gene mutations and characterization of the derived proteins in 35 X-linked agammaglobulinemia families: a nationwide study of Btk deficiency in Japan.Semantic proximity Read ↗

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