Article
Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.
Science signaling - 27 Aug 2013
Joseph Raji E, Kleino Iivari, Wales Thomas E, Xie Qian, Fulton D Bruce, Engen John R, Berg Leslie J, Andreotti Amy H
Abstract excerpt
Itk (interleukin-2-inducible T cell kinase) and Btk (Bruton's tyrosine kinase) are nonreceptor tyrosine kinases of the Tec family that signal downstream of the T cell receptor (TCR) and B cell receptor (BCR), respectively. Despite their high sequence similarity and related signaling roles, Btk is a substantially more active kinase than Itk. We showed that substitution of 6 of the 619 amino acid residues of Itk...
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