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Article

Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling.

Immunological reviews - 1 Feb 2005

Lindvall Jessica M, Blomberg K Emelie M, Väliaho Jouni, Vargas Leonardo, Heinonen Juhana E, Berglöf Anna, Mohamed Abdalla J, Nore Beston F, Vihinen Mauno, Smith C I Edvard

Abstract excerpt

Bruton's tyrosine kinase (Btk) is encoded by the gene that when mutated causes the primary immunodeficiency disease X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (Xid) in mice. Btk is a member of the Tec family of protein tyrosine kinases (PTKs) and plays a vital, but diverse, modulatory role in many cellular processes. Mutations affecting Btk block B-lymphocyte development. Btk is...

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Identifiers

PMID: 15661031
DOI: 10.1111/j.0105-2896.2005.00225.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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