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Article

Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia.

The EMBO journal - 16 Jun 1997

Hyvönen M, Saraste M

Abstract excerpt

Bruton's tyrosine kinase (Btk) is an enzyme which is involved in maturation of B cells. It is a target for mutations causing X-linked agammaglobulinaemia (XLA) in man. We have determined the structure of the N-terminal part of Btk by X-ray crystallography at 1.6 A resolution. This part of the kinase contains a pleckstrin homology (PH) domain and a Btk motif. The structure of the PH domain is similar to those...

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Identifiers

PMID: 9218782
DOI: 10.1093/emboj/16.12.3396
PMCID: PMC1169965

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