Article
Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia.
The EMBO journal - 16 Jun 1997
Hyvönen M, Saraste M
Abstract excerpt
Bruton's tyrosine kinase (Btk) is an enzyme which is involved in maturation of B cells. It is a target for mutations causing X-linked agammaglobulinaemia (XLA) in man. We have determined the structure of the N-terminal part of Btk by X-ray crystallography at 1.6 A resolution. This part of the kin...
Topics
- Agammaglobulinaemia Tyrosine Kinase
- Agammaglobulinemia
- Amino Acid Sequence
- Binding Sites
- Blood Proteins
- Crystallography, X-Ray
- Genetic Linkage
- Humans
- Image Processing, Computer-Assisted
- Inositol 1,4,5-Trisphosphate
- Molecular Sequence Data
- Mutation
- Phosphoproteins
- Protein Structure, Secondary
- Protein-Tyrosine Kinases
- Sequence Homology, Amino Acid
- X Chromosome