Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain.

Immunological reviews - 1 Mar 2009

Mohamed Abdalla J, Yu Liang, Bäckesjö Carl-Magnus, Vargas Leonardo, Faryal Rani, Aints Alar, Christensson Birger, Berglöf Anna, Vihinen Mauno, Nore Beston F, Smith C I Edvard

Abstract excerpt

Bruton's agammaglobulinemia tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase important in B-lymphocyte development, differentiation, and signaling. Btk is a member of the Tec family of kinases. Mutations in the Btk gene lead to X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (Xid) in mice. Activation of Btk triggers a cascade of signaling events that culminates in the generation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Agammaglobulinaemia Tyrosine Kinase
Share to Agammaglobulinemia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasms

Share to Protein Structure, Tertiary

Share to Protein-Tyrosine Kinases

Source

Identifiers

PMID: 19290921
DOI: 10.1111/j.1600-065X.2008.00741.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain.PMID 19290921Read ↗

TEC family kinases in health and disease--loss-of-function of BTK and ITK and the gain-of-function fusions ITK-SYK and BTK-SYK.Semantic proximity Read ↗

Signalling of Bruton's Tyrosine Kinase, BtkSemantic proximity Read ↗

PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.Semantic proximity Read ↗

Bruton's tyrosine kinase--an integral protein of B cell development that also has an essential role in the innate immune system.Semantic proximity Read ↗

Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia.Semantic proximity Read ↗

Bruton tyrosine kinase (BTK) in X-linked agammaglobulinemia (XLA).Semantic proximity Read ↗

X-linked agammaglobulinemia (XLA): a genetic tyrosine kinase (Btk) disease.Semantic proximity Read ↗

Mutation of the Pleckstrin Homology Domain of Bruton's Tyrosine Kinase in Immunodeficiency Impaired Inositol 1,3,4,5-Tetrakisphosphate Binding CapacitySemantic proximity Read ↗

Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases.Semantic proximity Read ↗

The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species.Semantic proximity Read ↗

Bruton's tyrosine kinase controls a sustained calcium signal essential for B lineage development and function.Semantic proximity Read ↗

E41K Mutation Activates Bruton’s Tyrosine Kinase by Stabilizing an Inositol Hexakisphosphate dependent Invisible DimerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.