Article
Identification and characterization of the DNA binding domain of CpG-binding protein.
The Journal of biological chemistry - 30 Nov 2001
Lee J H, Voo K S, Skalnik D G
Abstract excerpt
CpG-binding protein is a transcriptional activator that exhibits a unique DNA binding specificity for unmethylated CpG motifs. CpG-binding protein contains a cysteine-rich CXXC domain that is conserved in DNA methyltransferase 1, methyl binding domain protein 1, and human trithorax. In vitro DNA binding assays reveal that CpG-binding protein contains a single DNA binding domain comprised of the CXXC domain and a...
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