Article
A SILAC-based screen for Methyl-CpG binding proteins identifies RBP-J as a DNA methylation and sequence-specific binding protein.
PloS one - 1 Jan 2011
Bartels Stefanie J J, Spruijt Cornelia G, Brinkman Arie B, Jansen Pascal W T C, Vermeulen Michiel, Stunnenberg Hendrik G
Abstract excerpt
BACKGROUND: DNA methylation is an epigenetic modification that plays a crucial role in a variety of biological processes. Methylated DNA is specifically bound by Methyl-CpG Binding Proteins (MBPs). Three different types of MBPs have been identified so far: the Methyl-CpG Binding Domain (MBD) family proteins, three BTB/POZ-Zn-finger proteins, and UHRF1. Most of the known MBPs have been identified via homology with...
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