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Article

Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence.

Genes & development - 15 Oct 2014

Hashimoto Hideharu, Olanrewaju Yusuf Olatunde, Zheng Yu, Wilson Geoffrey G, Zhang Xing, Cheng Xiaodong

Abstract excerpt

In mammalian DNA, cytosine occurs in several chemical forms, including unmodified cytosine (C), 5-methylcytosine (5 mC), 5-hydroxymethylcytosine (5 hmC), 5-formylcytosine (5 fC), and 5-carboxylcytosine (5 caC). 5 mC is a major epigenetic signal that acts to regulate gene expression. 5 hmC, 5 fC, and 5 caC are oxidized derivatives that might also act as distinct epigenetic signals. We investigated the response of...

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PMID: 25258363
DOI: 10.1101/gad.250746.114
PMCID: PMC4201290

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Source receipt: pubmed, retrieved 7 Sept 2026.

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