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The Epstein-Barr Virus B-ZIP Protein Zta Recognizes Specific DNA Sequences Containing 5-Methylcytosine and 5-Hydroxymethylcytosine.

Biochemistry - 28 Nov 2017

Tillo Desiree, Ray Sreejana, Syed Khund-Sayeed, Gaylor Mary Rose, He Ximiao, Wang Jun, Assad Nima, Durell Stewart R, Porollo Aleksey, Weirauch Matthew T, Vinson Charles

Abstract excerpt

The Epstein-Barr virus (EBV) B-ZIP transcription factor Zta binds to many DNA sequences containing methylated CG dinucleotides. Using protein binding microarrays (PBMs), we analyzed the sequence specific DNA binding of Zta to four kinds of double-stranded DNA (dsDNA): (1) DNA containing cytosine in both strands, (2) DNA with 5-methylcytosine (5mC) in one strand and cytosine in the second strand, (3) DNA with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29072898
DOI: 10.1021/acs.biochem.7b00741
PMCID: PMC5907473

Genes

EBP

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