Article
The impact of population admixture on traditional linkage analysis.
Ethnicity & disease - 1 Jan 2001
Barnholtz-Sloan J S, de Andrade M, Chakraborty R
Abstract excerpt
INTRODUCTION: Families of admixed ancestry are routinely excluded from traditional (Log of the Odds [LOD] score) linkage analysis or are analyzed as being derived from a homogeneous population using the proband's ethnicity. Using traditional linkage analysis with these families can cause complications due to the mixing of different disease rates and allele frequencies that occurs. The presence of admixture...
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