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Article

Regression models for linkage heterogeneity applied to familial prostate cancer.

American journal of human genetics - 1 May 2001

Schaid D J, McDonnell S K, Thibodeau S N

Abstract excerpt

Linkage heterogeneity frequently occurs for complex genetic diseases, and statistical methods must account for it to avoid severe loss in power to discover susceptibility genes. A common method to allow for only a fraction of linked pedigrees is to fit a mixture likelihood and then to test for linkage homogeneity, given linkage (admixture test), or to test for linkage while allowing for heterogeneity, using the...

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PMID: 11309684
DOI: 10.1086/320102
PMCID: PMC1226099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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