Article
Linkage analysis of a complex disease through use of admixed populations.
American journal of human genetics - 1 Jun 2004
Zhu Xiaofeng, Cooper Richard S, Elston Robert C
Abstract excerpt
Linkage disequilibrium arising from the recent admixture of genetically distinct populations can be potentially useful in mapping genes for complex diseases. McKeigue has proposed a method that conditions on parental admixture to detect linkage. We show that this method tests for linkage only under specific assumptions, such as equal admixture in the parental generation and admixture that occurs in a single...
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