Article
p53 has a direct apoptogenic role at the mitochondria.
Molecular cell - 1 Mar 2003
Mihara Motohiro, Erster Susan, Zaika Alexander, Petrenko Oleksi, Chittenden Thomas, Pancoska Petr, Moll Ute M
Abstract excerpt
p53 induces apoptosis by target gene regulation and transcription-independent signaling. However, a mechanism for the latter was unknown. We recently reported that a fraction of induced p53 translocates to the mitochondria of apoptosing tumor cells. Targeting p53 to mitochondria is sufficient to launch apoptosis. Here, we provide evidence that p53 translocation to the mitochondria occurs in vivo in irradiated...
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