Specific interaction of mutant p53 with regions of matrix attachment region DNA elements (MARs) with a high potential for base-unpairing.

doi:10.1073/pnas.95.23.13681

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Article

Specific interaction of mutant p53 with regions of matrix attachment region DNA elements (MARs) with a high potential for base-unpairing.

Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 1998

Will K, Warnecke G, Wiesmüller L, Deppert W

Abstract excerpt

Mutant, but not wild-type p53 binds with high affinity to a variety of MAR-DNA elements (MARs), suggesting that MAR-binding of mutant p53 relates to the dominant-oncogenic activities proposed for mutant p53. MARs recognized by mutant p53 share AT richness and contain variations of an AATATATTT "D...

Topics

Animals
Base Pairing
Binding Sites
DNA
DNA-Binding Proteins
Humans
Mice
Mutation
Protein Binding
Tumor Suppressor Protein p53

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