Could capillary zone electrophoresis of tryptic peptides be used for the characterization of hemoglobin variants?

doi:10.1081/hem-100105219

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Article

Could capillary zone electrophoresis of tryptic peptides be used for the characterization of hemoglobin variants?

Hemoglobin - 1 Aug 2001

Lin C, Gulbis B, Delobbe E, Robberecht P, Cotton F, Fontaine B, Vertongen F

Abstract excerpt

The present article describes a simple and rapid new peptide mapping procedure that could be used to assist identification of rare hemoglobin variants in clinical laboratories. Four hemoglobin variants were taken as example, namely Hb D-Ouled Rabah, Hb Marseille, Hb G-Philadelphia, and Hb Ube-2, and isolated by electrophoresis at alkaline pH. The globin chains were aminoethylated and, after tryptic digestion, the...

Topics

Amino Acid Sequence
Electrophoresis, Capillary
Genetic Variation
Globins
Hemoglobins, Abnormal
Humans
Peptide Fragments
Peptide Mapping
Reproducibility of Results
Trypsin

Source

Open in PubMed

Identifiers

PMID: 11570719
DOI: 10.1081/hem-100105219

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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