Article
Protein characterization by LC-MS/MS may be required for the DNA identification of a fusion hemoglobin: the example of Hb P-Nilotic.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences - 1 Feb 2012
Zanella-Cleon Isabelle, Delolme Frédéric, Lacan Philippe, Garcia Caroline, Vinatier Isabelle, Francina Alain, Joly Philippe
Abstract excerpt
DNA analysis is currently the easiest way to identify a hemoglobin variant in most cases. Nevertheless, in case of complex gene rearrangements, mass spectrometry studies may be required to orientate the DNA diagnosis. The present report shows the use of mass spectrometry techniques prior to DNA analysis for the identification of the rare P-Nilotic fusion hemoglobin. Complete protein analysis is performed by...
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