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Article

A novel tandem mass spectrometry method for first-line screening of mainly beta-thalassemia from dried blood spots.

Journal of proteomics - 10 Feb 2017

Yu Chaowen, Huang Shuodan, Wang Ming, Zhang Juan, Liu Hao, Yuan Zhaojian, Wang Xingbin, He Xiaoyan, Wang Jie, Zou Lin

Abstract excerpt

Traditional methods for thalassemia screening are time-consuming and easily affected by cell hemolysis or hemoglobin degradation in stored blood samples. Tandem mass spectrometry (MS/MS) proved to be an effective technology for sickle cell disorders (SCD) screening. Here, we developed a novel MS/MS method for β-thalassemia screening from dried blood spots (DBS). Stable isotopic-labeled peptides were used as...

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Identifiers

PMID: 28007617
DOI: 10.1016/j.jprot.2016.12.008

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SCD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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