Article
Phenotype determination of hemoglobinopathies by mass spectrometry.
Clinical biochemistry - 1 Dec 2009
Zanella-Cleon Isabelle, Joly Philippe, Becchi Michel, Francina Alain
Abstract excerpt
OBJECTIVES: Nowadays, nearly 1000 hemoglobin (Hb) variants are known. The standard biochemical techniques used in Hb analysis are mainly: isoelectric focusing, cation-exchange liquid chromatography (LC) and reversed-phase LC. In addition to this approach, a protein analysis is achieved by mass spectrometry (MS) and additional DNA studies are performed. The aim of this review is to emphasize the significance of MS...
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