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Article

Identification of hemoglobin variants by top-down mass spectrometry using selected diagnostic product ions.

Analytical and bioanalytical chemistry - 1 Apr 2015

Coelho Graça Didia, Hartmer Ralf, Jabs Wolfgang, Beris Photis, Clerici Lorella, Stoermer Carsten, Samii Kaveh, Hochstrasser Denis, Tsybin Yury O, Scherl Alexander, Lescuyer Pierre

Abstract excerpt

Hemoglobin disorder diagnosis is a complex procedure combining several analytical steps. Due to the lack of specificity of the currently used protein analysis methods, the identification of uncommon hemoglobin variants (proteoforms) can become a hard task to accomplish. The aim of this work was to develop a mass spectrometry-based approach to quickly identify mutated protein sequences within globin chain...

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PMID: 25753013
DOI: 10.1007/s00216-015-8525-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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