Article
Mutational analysis of ligand-induced activation of the Torpedo acetylcholine receptor.
The Journal of biological chemistry - 25 Apr 1992
O'Leary M E, White M M
Abstract excerpt
A number of studies have demonstrated that a major portion of the ligand binding site of the Torpedo nicotinic acetylcholine receptor is near cysteines 192 and 193 of the alpha subunit. The role of conserved tyrosine and aspartate residues within this region in ligand binding and receptor activat...
Topics
- Amino Acid Sequence
- Animals
- DNA
- Ligands
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Quaternary Ammonium Compounds
- Receptors, Cholinergic
- Sequence Homology, Nucleic Acid
- Torpedo
- Transcription, Genetic
- Xenopus