Article
Abnormal adherence junctions in the heart and reduced angiogenesis in transgenic mice overexpressing mutant type XIII collagen.
The EMBO journal - 17 Sept 2001
Sund M, Ylönen R, Tuomisto A, Sormunen R, Tahkola J, Kvist A P, Kontusaari S, Autio-Harmainen H, Pihlajaniemi T
Abstract excerpt
Type XIII collagen is a type II transmembrane protein found at sites of cell adhesion. Transgenic mouse lines were generated by microinjection of a DNA construct directing the synthesis of truncated alpha1(XIII) chains. Shortened alpha 1(XIII) chains were synthesized by fibroblasts from mutant mice, and the lack of intracellular accumulation in immunofluorescent staining of tissues suggested that the mutant...
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