Transmembrane collagen XVII is a novel component of the glomerular filtration barrier.

doi:10.1007/s00441-012-1368-x

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Article

Transmembrane collagen XVII is a novel component of the glomerular filtration barrier.

Cell and tissue research - 1 Jun 2012

Hurskainen Tiina, Moilanen Jyri, Sormunen Raija, Franzke Claus-Werner, Soininen Raija, Loeffek Stefanie, Huilaja Laura, Nuutinen Matti, Bruckner-Tuderman Leena, Autio-Harmainen Helena, Tasanen Kaisa

Abstract excerpt

The kidney filtration barrier consists of the capillary endothelium, the glomerular basement membrane and the slit diaphragm localized between foot processes of neighbouring podocytes. We report that collagen XVII, a transmembrane molecule known to be required for epithelial adhesion, is expressed in podocytes of normal human and mouse kidneys and in endothelial cells of the glomerular filtration barrier....

Topics

Animals
Autoantigens
Child, Preschool
Female
Glomerular Basement Membrane
Glomerular Filtration Barrier
Humans
Mice
Mice, Knockout
Non-Fibrillar Collagens
Phenotype
Collagen Type XVII

Source

Open in PubMed

Identifiers

PMID: 22457199
DOI: 10.1007/s00441-012-1368-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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