Large and small splice variants of collagen XII: differential expression and ligand binding.

doi:10.1083/jcb.130.4.1005

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Article

Large and small splice variants of collagen XII: differential expression and ligand binding.

The Journal of cell biology - 1 Aug 1995

Koch M, Bohrmann B, Matthison M, Hagios C, Trueb B, Chiquet M

Abstract excerpt

Collagen XII has a short collagenous tail and a very large, three-armed NC3 domains consisting primarily of fibronectin type III repeats. Differential splicing within this domain gives rise to a large (320 kD) and a small (220 kD) subunit; the large but not the small can carry glycosaminoglycan. To investigate whether collagen XII variants have distinct expression patterns and functions, we generated antibody and...

Topics

Alternative Splicing
Animals
Antibodies, Monoclonal
Antibody Specificity
Blotting, Northern
Chick Embryo
Cloning, Molecular
Collagen
DNA, Complementary
Feathers
Fluorescent Antibody Technique

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Heparin

Immunoblotting

In Situ Hybridization

Ligands

Microscopy, Electron

Particle Size

Source

Open in PubMed Open full text

Identifiers

PMID: 7642694
DOI: 10.1083/jcb.130.4.1005
PMCID: PMC2199960

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7642694-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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