Article
Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice.
Development (Cambridge, England) - 1 Feb 1995
Kwee L, Baldwin H S, Shen H M, Stewart C L, Buck C, Buck C A, Labow M A
Abstract excerpt
VCAM-1 is a cytokine-inducible cell surface protein capable of mediating adhesion to leukocytes expressing alpha 4 integrins. Mice deficient in VCAM-1 expression were produced by targeted homologous recombination in ES cells. VCAM-1-deficient embryos were not viable and exhibited either of two di...
Topics
- Allantois
- Animals
- Antigens, CD
- Cardiovascular System
- Cell Adhesion Molecules
- Chorion
- Fetal Death
- Gene Expression
- Genotype
- Heart
- Immunohistochemistry
- Integrin alpha4
- Mice
- Mice, Mutant Strains
- Placenta
- Placentation
- Receptors, Lymphocyte Homing
- Vascular Cell Adhesion Molecule-1