Skeletal development in transgenic mice expressing a mutation at Gly574Ser of type II collagen.

doi:10.1002/(SICI)1097-0177(199702)208:2<170::AID-AJA4>3.0.CO;2-F

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Article

Skeletal development in transgenic mice expressing a mutation at Gly574Ser of type II collagen.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Feb 1997

Maddox B K, Garofalo S, Smith C, Keene D R, Horton W A

Abstract excerpt

Skeletal development of transgenic mice with a type II collagen mutation was analyzed and compared with wild-type littermates. The single base substitution in Col2a1 resulted in a glycine to serine mutation within the helical domain and corresponded to one previously identified in a patient with...

Topics

Animals
Bone Development
Female
Glycine
Male
Mice
Mice, Transgenic
Phenotype
Point Mutation
Serine

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