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Article

Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin.

Development (Cambridge, England) - 1 Dec 1993

George E L, Georges-Labouesse E N, Patel-King R S, Rayburn H, Hynes R O

Abstract excerpt

To examine the role of fibronectin in vivo, we have generated mice in which the fibronectin gene is inactivated. Heterozygotes have one half normal levels of plasma fibronectin, yet appear normal. When homozygous, the mutant allele causes early embryonic lethality, proving that fibronectin is req...

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PMID: 8306876
DOI: 10.1242/dev.119.4.1079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8306876-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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