Article
Heterozygous mice for the transforming growth factor-beta type II receptor gene have increased susceptibility to hepatocellular carcinogenesis.
Cancer research - 15 Sept 2001
Im Y H, Kim H T, Kim I Y, Factor V M, Hahm K B, Anzano M, Jang J J, Flanders K, Haines D C, Thorgeirsson S S, Sizeland A, Kim S J
Abstract excerpt
The transforming growth factor-beta (TGF-beta) receptor complex and its downstream signaling intermediates constitute a tumor suppressor pathway. In many cancers, expression of TGF-beta type II receptor (TbetaR-II) is markedly decreased. In the present study, we show that the hepatocytes isolated from 15-day-old, but not 9-month-old, mice heterozygous for the deletion of the TbetaR-II gene are slightly less...
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