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Article

Epithelial Transforming Growth Factor-β Signaling Does Not Contribute to Liver Fibrosis but Protects Mice From Cholangiocarcinoma.

Gastroenterology - 1 Mar 2016

Mu Xueru, Pradere Jean-Philippe, Affò Silvia, Dapito Dianne H, Friedman Richard, Lefkovitch Jay H, Schwabe Robert F

Abstract excerpt

BACKGROUND & AIMS: Transforming growth factor-β (TGFβ) exerts key functions in fibrogenic cells, promoting fibrosis development in the liver and other organs. In contrast, the functions of TGFβ in liver epithelial cells are not well understood, despite their high level of responsiveness to TGFβ. We sought to determine the contribution of epithelial TGFβ signaling to hepatic fibrogenesis and carcinogenesis....

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Source

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Identifiers

PMID: 26627606
DOI: 10.1053/j.gastro.2015.11.039
PMCID: PMC6490681

Genes

PTEN
TGFBR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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