Molecular and genetic analysis of liver oncogenesis in transforming growth factor alpha transgenic mice.

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Article

Molecular and genetic analysis of liver oncogenesis in transforming growth factor alpha transgenic mice.

Cancer research - 1 Oct 1992

Takagi H, Sharp R, Hammermeister C, Goodrow T, Bradley M O, Fausto N, Merlino G

Abstract excerpt

Overexpression of a transforming growth factor alpha (TGF-alpha) transgene induced the development of liver tumors in 69 of 93 (74%) adult male mice. To identify factors associated with oncogenesis, liver tumors from transgenic animals were characterized at the molecular level. TGF-alpha RNA tran...

Topics

Animals
Base Sequence
DNA
DNA, Neoplasm
Disease Models, Animal
Female
Gene Expression
Gonadal Steroid Hormones
Growth Substances
Liver Neoplasms, Experimental
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Molecular Sequence Data
Oncogenes
Phenotype
RNA, Neoplasm

Source

Open in PubMed

Identifiers

PMID: 1394122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1394122-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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