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Molecular and genetic analysis of liver oncogenesis in transforming growth factor alpha transgenic mice.

Cancer research - 1 Oct 1992

Takagi H, Sharp R, Hammermeister C, Goodrow T, Bradley M O, Fausto N, Merlino G

Abstract excerpt

Overexpression of a transforming growth factor alpha (TGF-alpha) transgene induced the development of liver tumors in 69 of 93 (74%) adult male mice. To identify factors associated with oncogenesis, liver tumors from transgenic animals were characterized at the molecular level. TGF-alpha RNA transcripts were elevated in 17 of 25 (68%) liver tumors, relative to adjacent nontumorous tissue. Expression of the...

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PMID: 1394122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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