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Article

Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice.

EMBO reports - 1 Jun 2003

Yen Paul M, Feng Xu, Flamant Frederic, Chen Yidong, Walker Robert L, Weiss Roy E, Chassande Olivier, Samarut Jacques, Refetoff Samuel, Meltzer Paul S

Abstract excerpt

Little is known about the overall patterns of thyroid hormone (Th)-mediated gene regulation by the main Th receptor (Tr) isoforms, Tr-alpha and Tr-beta, in vivo. We used 48 complementary DNA microarrays to examine hepatic gene expression profiles of wild-type and Thra and Thrb knockout mice under different Th conditions: no treatment, treatment with 3,3',5-triiodothyronine (T(3)), Th-deprivation using...

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Identifiers

PMID: 12776178
DOI: 10.1038/sj.embor.embor862
PMCID: PMC1319202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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