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Article

Inhibition of the membrane fusion machinery prevents exit from the TGN and proteolytic processing by furin.

FEBS letters - 7 Sept 2001

Band A M, Määttä J, Kääriäinen L, Kuismanen E

Abstract excerpt

The Semliki Forest virus (SFV) glycoprotein precursor p62 is processed to the E2 and E3 during the transport from the trans-Golgi network (TGN) to the cell surface. We have studied the regulation of the membrane fusion machinery (Rab/N-ethylmaleimide (NEM)-sensitive fusion protein (NSF)/soluble NSF attachment protein (SNAP)-SNAP receptor) in this processing. Activation of the disassembly of this complex with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11557053
DOI: 10.1016/s0014-5793(01)02798-3

Genes

NSF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of the membrane fusion machinery prevents exit from the TGN and proteolytic processing by furin.PMID 11557053Read ↗

Processing of the p62 envelope precursor protein of Semliki Forest virus.Semantic proximity Read ↗

Fusion function of the Semliki Forest virus spike is activated by proteolytic cleavage of the envelope glycoprotein precursor p62.Semantic proximity Read ↗

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Proteolytic processing of the Marburg virus glycoprotein depends on Sec61β and is required for cell entrySemantic proximity Read ↗

The nucleocapsid-binding spike subunit E2 of Semliki Forest virus requires complex formation with the E1 subunit for activity.Semantic proximity Read ↗

SNARE mimicry by the CD225 domain of IFITM3 enables regulation of homotypic late endosome fusionSemantic proximity Read ↗

Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization.Semantic proximity Read ↗

Fusion of cells by flipped SNAREs.Semantic proximity Read ↗

A conserved membrane attachment site in alpha-SNAP facilitates N-ethylmaleimide-sensitive factor (NSF)-driven SNARE complex disassembly.Semantic proximity Read ↗

Mutations that promote furin-independent growth of Semliki Forest virus affect p62-E1 interactions and membrane fusion.Semantic proximity Read ↗

An interaction site of the envelope proteins of Semliki Forest virus that is preserved after proteolytic activation.Semantic proximity Read ↗

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