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Article

An interaction site of the envelope proteins of Semliki Forest virus that is preserved after proteolytic activation.

Virology - 5 Jul 2005

Zhang Xinyong, Kielian Margaret

Abstract excerpt

Semliki Forest virus (SFV) membrane fusion is mediated by the viral E1 protein at acidic pH and regulated by the dimeric interaction of E1 with the E2 membrane protein. During low pH-triggered fusion, the E2/E1 heterodimer dissociates, freeing E1 to drive membrane fusion. E2 is synthesized as a precursor, p62, which is processed to mature E2 by the cellular protease furin. Both the dissociation of the p62/E1...

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Identifiers

PMID: 15913697
DOI: 10.1016/j.virol.2005.04.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An interaction site of the envelope proteins of Semliki Forest virus that is preserved after proteolytic activation.PMID 15913697Read ↗

Mutations that promote furin-independent growth of Semliki Forest virus affect p62-E1 interactions and membrane fusion.Semantic proximity Read ↗

Fusion function of the Semliki Forest virus spike is activated by proteolytic cleavage of the envelope glycoprotein precursor p62.Semantic proximity Read ↗

fus-1, a pH shift mutant of Semliki Forest virus, acts by altering spike subunit interactions via a mutation in the E2 subunit.Semantic proximity Read ↗

An Alphavirus E2 Membrane-Proximal Domain Promotes Envelope Protein Lateral Interactions and Virus Budding.Semantic proximity Read ↗

A conserved histidine in the ij loop of the Semliki Forest virus E1 protein plays an important role in membrane fusion.Semantic proximity Read ↗

Role of conserved histidine residues in the low-pH dependence of the Semliki Forest virus fusion protein.Semantic proximity Read ↗

Structure and interactions at the viral surface of the envelope protein E1 of Semliki Forest virus.Semantic proximity Read ↗

Spike protein oligomerization control of Semliki Forest virus fusion.Semantic proximity Read ↗

Processing of the p62 envelope precursor protein of Semliki Forest virus.Semantic proximity Read ↗

The dynamic envelope of a fusion class II virus. E3 domain of glycoprotein E2 precursor in Semliki Forest virus provides a unique contact with the fusion protein E1.Semantic proximity Read ↗

The nucleocapsid-binding spike subunit E2 of Semliki Forest virus requires complex formation with the E1 subunit for activity.Semantic proximity Read ↗

The domain I-domain III linker plays an important role in the fusogenic conformational change of the alphavirus membrane fusion protein.Semantic proximity Read ↗

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