Fusion function of the Semliki Forest virus spike is activated by proteolytic cleavage of the envelope glycoprotein precursor p62.

doi:10.1128/JVI.64.3.1233-1240.1990

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Article

Fusion function of the Semliki Forest virus spike is activated by proteolytic cleavage of the envelope glycoprotein precursor p62.

Journal of virology - 1 Mar 1990

Lobigs M, Garoff H

Abstract excerpt

The precursor protein p62 of the prototype alphavirus Semliki Forest virus (SFV) undergoes during transport to the cell surface a proteolytic cleavage to form the mature envelope glycoprotein E2. To investigate the biological significance of this cleavage event, single amino acid substitutions we...

Topics

Animals
Base Sequence
Cell Line
Kinetics
Molecular Sequence Data
Mutation
Oligonucleotide Probes
Plasmids
Protein Precursors
Protein Processing, Post-Translational
Semliki forest virus
Trypsin
Viral Envelope Proteins
Viral Proteins

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