Article

Proteolytic processing of the Marburg virus glycoprotein depends on Sec61β and is required for cell entry

2025-06-26

Abstract excerpt

Ebola and Marburg virus (EBOV, MARV) cause severe disease and therapeutic options are urgently needed. The Sec61 translocon facilitates ER import of viral glycoproteins (GPs) and may represent a therapeutic target. Here, we report that the Sec61 subunit Sec61β, although dispensable for GP expression, is required for proteolytic cleavage of MARV- but not EBOV-GP and that an intact furin motif is essential for robus...

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Literature Corpus work: 386e7486-a614-5d6b-b34a-3f90e83f8e3f
DOI: 10.1101/2025.06.26.660697

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