Article
The nucleocapsid-binding spike subunit E2 of Semliki Forest virus requires complex formation with the E1 subunit for activity.
Journal of virology - 1 Oct 1997
Barth B U, Garoff H
Abstract excerpt
Alphaviruses, such as Semliki Forest virus (SFV), mature by budding at the plasma membrane (PM) of infected cells and enter uninfected ones by a membrane fusion process in the endosomes. Both processes are directed by the p62/E2-E1 membrane protein heterodimer of the virus. The p62 protein, or it...
Topics
- Animals
- Antibodies, Monoclonal
- Cell Line
- Cricetinae
- Dimerization
- Endosomes
- Genetic Variation
- Genome, Viral
- Macromolecular Substances
- Membrane Fusion
- Molecular Weight
- Protein Biosynthesis
- Protein Engineering
- RNA, Viral
- Recombinant Proteins
- Semliki forest virus
- Transfection
- Viral Envelope Proteins