Mutations that promote furin-independent growth of Semliki Forest virus affect p62-E1 interactions and membrane fusion.

doi:10.1016/j.virol.2004.06.037

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Article

Mutations that promote furin-independent growth of Semliki Forest virus affect p62-E1 interactions and membrane fusion.

Virology - 1 Oct 2004

Zhang Xinyong, Kielian Margaret

Abstract excerpt

The enveloped alphavirus Semliki Forest virus (SFV) infects cells via a low pH-triggered membrane fusion reaction mediated by the E1 protein. E1's fusion activity is regulated by its heterodimeric interaction with a companion membrane protein E2. Mature E2 protein is generated by furin processing of the precursor p62. Processing destabilizes the heterodimer, allowing dissociation at acidic pH, E1 conformational...

Topics

Amino Acid Sequence
Animals
Cell Line
Cricetinae
Dimerization
Furin
Gene Expression Regulation, Viral
Membrane Fusion
Mutation
Protein Precursors
Semliki forest virus
Viral Envelope Proteins

Source

Open in PubMed

Identifiers

PMID: 15351216
DOI: 10.1016/j.virol.2004.06.037

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