Article
Fusion of cells by flipped SNAREs.
Science (New York, N.Y.) - 13 Jun 2003
Hu Chuan, Ahmed Mahiuddin, Melia Thomas J, Söllner Thomas H, Mayer Thomas, Rothman James E
Abstract excerpt
The SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) hypothesis suggests that pairs of proteins known as vesicle (v-) SNAREs and target membrane (t-) SNAREs interact specifically to control and mediate intracellular membrane fusion events. Here, cells expressing the interacting domains of v- and t-SNAREs on the cell surface were found to fuse spontaneously, demonstrating that SNAREs...
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