Article
Control of microtubule dynamics by Stu2p is essential for spindle orientation and metaphase chromosome alignment in yeast.
Molecular biology of the cell - 1 Sept 2001
Kosco K A, Pearson C G, Maddox P S, Wang P J, Adams I R, Salmon E D, Bloom K, Huffaker T C
Abstract excerpt
Stu2p is a member of a conserved family of microtubule-binding proteins and an essential protein in yeast. Here, we report the first in vivo analysis of microtubule dynamics in cells lacking a member of this protein family. For these studies, we have used a conditional Stu2p depletion strain expressing alpha-tubulin fused to green fluorescent protein. Depletion of Stu2p leads to fewer and less dynamic cytoplasmic...
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