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Article

Kinetochores generate microtubules with distal plus ends: their roles and limited lifetime in mitosis.

Developmental cell - 16 Feb 2010

Kitamura Etsushi, Tanaka Kozo, Komoto Shinya, Kitamura Yoko, Antony Claude, Tanaka Tomoyuki U

Abstract excerpt

In early mitosis, microtubules can be generated at kinetochores as well as at spindle poles. However, the role and regulation of kinetochore-derived microtubules have been unclear. In general, metaphase spindle microtubules are oriented such that their plus ends bind to kinetochores. However, we now have evidence that, during early mitosis in budding yeast, microtubules are generated at kinetochores with distal...

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Identifiers

PMID: 20159595
DOI: 10.1016/j.devcel.2009.12.018
PMCID: PMC2828607

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