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Article

Myosin Va bound to phagosomes binds to F-actin and delays microtubule-dependent motility.

Molecular biology of the cell - 1 Sept 2001

Al-Haddad A, Shonn M A, Redlich B, Blocker A, Burkhardt J K, Yu H, Hammer J A, Weiss D G, Steffen W, Griffiths G, Kuznetsov S A

Abstract excerpt

We established a light microscopy-based assay that reconstitutes the binding of phagosomes purified from mouse macrophages to preassembled F-actin in vitro. Both endogenous myosin Va from mouse macrophages and exogenous myosin Va from chicken brain stimulated the phagosome-F-actin interaction. Myosin Va association with phagosomes correlated with their ability to bind F-actin in an ATP-regulated manner and...

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Identifiers

PMID: 11553713
DOI: 10.1091/mbc.12.9.2742
PMCID: PMC59709

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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