Article
The different roles of V-ATPase a subunits in phagocytosis/endocytosis and autophagy.
Autophagy - 1 Oct 2024
Chen Qi, Kou Hanjing, Demy Doris Lou, Liu Wei, Li Jianchao, Wen Zilong, Herbomel Philippe, Huang Zhibin, Zhang Wenqing, Xu Jin
Abstract excerpt
Microglia are specialized macrophages responsible for the clearance of dead neurons and pathogens by phagocytosis and degradation. The degradation requires phagosome maturation and acidification provided by the vesicular- or vacuolar-type H+-translocating adenosine triphosphatase (V-ATPase), which is composed of the cytoplasmic V1 domain and the membrane-embedded Vo domain. The V-ATPase a subunit, an integral...
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