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Article

Expression of constructs of the neuronal isoform of myosin-Va interferes with the distribution of melanosomes and other vesicles in melanoma cells.

Cell motility and the cytoskeleton - 1 Feb 2002

da Silva Bizario João Carlos, da Cunha Nascimento Alexandra Aparecida, Casaletti Luciana, Patussi Eliana Valéria, Chociay Maria Fernanda, Larson Roy Edward, Espreafico Enilza Maria

Abstract excerpt

Myosin-Va has been implicated in melanosome translocation, but the exact molecular mechanisms underlying this function are not known. In the dilute, S91 melanoma cells, melanosomes move to the cell periphery but do not accumulate in the tips of dendrites as occurs in wild-type B16 melanocytes; ra...

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Identifiers

PMID: 11921164
DOI: 10.1002/cm.10010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-11921164-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

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Expression of constructs of the neuronal isoform of myosin-Va interferes with the distribution of melanosomes and other vesicles in melanoma cells.PMID 11921164Read ↗

Knockdown of myosin Va isoforms by RNAi as a tool to block melanosome transport in primary human melanocytes.Semantic proximity Read ↗

Rab27a enables myosin Va-dependent melanosome capture by recruiting the myosin to the organelle.Semantic proximity Read ↗

A tissue-specific exon of myosin Va is responsible for selective cargo binding in melanocytes.Semantic proximity Read ↗

Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes.Semantic proximity Read ↗

Myosin Va movements in normal and dilute-lethal axons provide support for a dual filament motor complex.Semantic proximity Read ↗

More than just a cargo adapter, melanophilin prolongs and slows processive runs of myosin Va.Semantic proximity Read ↗

The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes.Semantic proximity Read ↗

Identification of an organelle receptor for myosin-Va.Semantic proximity Read ↗

Melanophilin, the product of the leaden locus, is required for targeting of myosin-Va to melanosomes.Semantic proximity Read ↗

Rab27a regulates the peripheral distribution of melanosomes in melanocytes.Semantic proximity Read ↗

Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport.Semantic proximity Read ↗

The actin-binding domain of Slac2-a/melanophilin is required for melanosome distribution in melanocytes.Semantic proximity Read ↗

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