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Article

A myosin IK-Abp1-PakB circuit acts as a switch to regulate phagocytosis efficiency.

Molecular biology of the cell - 1 May 2010

Dieckmann Régis, von Heyden Yosuke, Kistler Claudia, Gopaldass Navin, Hausherr Stéphanie, Crawley Scott William, Schwarz Eva C, Diensthuber Ralph P, Côté Graham P, Tsiavaliaris Georgios, Soldati Thierry

Abstract excerpt

Actin dynamics and myosin (Myo) contractile forces are necessary for formation and closure of the phagocytic cup. In Dictyostelium, the actin-binding protein Abp1 and myosin IK are enriched in the closing cup and especially at an actin-dense constriction furrow formed around the neck of engulfed budded yeasts. This phagocytic furrow consists of concentric overlapping rings of MyoK, Abp1, Arp3, coronin, and myosin...

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Identifiers

PMID: 20200225
DOI: 10.1091/mbc.e09-06-0485
PMCID: PMC2861610

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